abstract：:Clinicians have long suspected that hypertrophied hearts have an inadequate coronary circulation. This clinical suspicion resulted from the observation that a large proportion of patients with left ventricular hypertrophy who have normal coronary arteriograms complain of angina and have ischaemia-like ST segment depre...

journal_title：European heart journal

authors： Kaski JC

更新日期：1993-11-01 00:00:00

abstract：:Left ventricular pressure overload results in the development of left ventricular hypertrophy (LVH) which is considered an adaptive mechanism of the heart to normalize systolic wall-stress. Impairment of both contractility and relaxation occurs, implying that the hypertrophied myocardium is very sensitive to ischaemia...

journal_title：European heart journal

authors： Viallard JF,Bonoron-Adele S,Dos Santos P,Coste P,Besse P

更新日期：1993-11-01 00:00:00

abstract：:The prevalence of left ventricular (LV) thrombosis and incidence of arterial embolism after acute anterior myocardial infarction (AAMI) treated with streptokinase 1.5 x 10(6) IU intravenously was studied in 136 patients enrolled consecutively in five cardiological centres. Adjunctive antithrombotic therapy was adminis...

journal_title：European heart journal

authors： Kontny F,Dale J,Hegrenaes L,Lem P,Søberg T,Morstøl T

更新日期：1993-11-01 00:00:00

abstract：:Alterations in the right ventricular function may or may not contribute to progressive cardiac dysfunction after left ventricular infarction. Ligation of the left coronary artery (LCAL) was lethal within 24 h for 25% of 100 rats, whereas none of 21 sham-operated rats died. No rats died during the following 4 weeks, af...

journal_title：European heart journal

authors： Christiansen EH,Tian R,Böttcher M,Andreasen F

更新日期：1993-11-01 00:00:00

abstract：:ACE inhibitors may influence the actual concentrations of the peptides angiotensin I, angiotensin II and bradykinin. Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited. ...

journal_title：European heart journal

authors： Dominiak P

更新日期：1993-11-01 00:00:00

abstract：:The endothelins are a family of three widely expressed 21 amino acid peptides. Apart from the ability to constrict vascular smooth muscle, they have numerous other potent effects, from enhancing mitogenesis to influencing nervous function. The pathway of their production involves the initial synthesis of a predominant...

journal_title：European heart journal

authors： Warner TD

更新日期：1993-11-01 00:00:00

abstract：:Transluminal coronary angioplasty (PTCA) is a well defined controlled model inducing regional myocardial ischaemia in man. Direct cardiac anti-ischaemic effects of anti-anginal drugs can be assessed by intracoronary injection of small doses which do not affect systemic parameters. Trimetazidine (TMZ) has recently been...

journal_title：European heart journal

authors： Kober G,Pennaforte S,Buck T,Sievert H,Vallbracht C

更新日期：1993-11-01 00:00:00

abstract：:The present review summarizes the available information on the effects of the three major classes of antianginal agents (nitrates, calcium and beta-blockers) on myocardial energy metabolism. It also discusses the role of some new molecules (L-carnitine, trimetazidine and ranolazine) that have been proposed as an alter...

journal_title：European heart journal

authors： Chierchia SL,Fragasso G

更新日期：1993-11-01 00:00:00

abstract：:It is only in the last few years that the broad-spectrum antiarrhythmic properties of sotalol have become increasingly recognized. Racemic sotalol has potent beta-blocking and class III antiarrhythmic properties, and it has been reported that this drug is able to control supraventricular and ventricular arrhythmias. R...

journal_title：European heart journal

authors： Aliot E,Sadoul N,De Chillou C

更新日期：1993-11-01 00:00:00

abstract：:Twenty-nine men with chronic stable angina pectoris were investigated using stress electrocardiography (ECG) and stress transthoracic echocardiography by means of transoesophageal stimulation of the left atrium. At rest and after each stimulated frequency, ECG and 2-dimensional echocardiography combined with Doppler w...

journal_title：European heart journal

authors： Meluzín J,Novák M,Julínek J,Rihácek I,Urbánek D,Koukalová H,Toman J

更新日期：1993-10-01 00:00:00

abstract：:The impulses coming from the sinus node synchronically penetrate the AV node via the crista terminalis and inter-atrial septum. Studies in superfused rabbit AV preparations suggest that the crista terminalis is a more effective input than the inter-atrial septum, and that the summation of both inputs facilitates AV no...

journal_title：European heart journal

authors： Sanchis J,Chorro FJ,Such L,Matamoros J,Monmeneu JV,Cortina J,López Merino V

更新日期：1993-10-01 00:00:00

abstract：:The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglio...

journal_title：European heart journal

authors： Malfatto G,Pessano P,Zaza A,Schwartz PJ

更新日期：1993-09-01 00:00:00

abstract：:To examine whether increases in heart rate might be a common trigger of angina at rest, changes in heart rate, blood pressure and rate-pressure product during pain were compared with the ischaemic threshold (heart rate with ST segment shift > = 1 mm), determined by atrial pacing, in 272 patients with unstable angina. ...

journal_title：European heart journal

authors： Figueras J,Lidón RM,Serés L

更新日期：1993-09-01 00:00:00

abstract：:Activation of the sympathetic nervous system may contribute to the renal vasoconstriction and sodium retention seen in congestive heart failure. Previous studies in congestive heart failure patients employing large doses of prazosin that lowered systemic blood pressure have been generally disappointing. The renal haem...

journal_title：European heart journal

authors： Lang CC,Choy AM,Rahman AR,Struthers AD

更新日期：1993-09-01 00:00:00

abstract：:Supraventricular tachycardia is due to altered automaticity, triggered activity or most commonly, reentry. Atrial flutter is most frequently due to reentry with counterclockwise activation in the right atrium with the left atrium acting as a bystander. The small wavefronts demonstrated during atrial fibrillation are l...

journal_title：European heart journal

authors： Shakespeare CF,Anderson M,Camm AJ

更新日期：1993-09-01 00:00:00

abstract：:A time-domain signal-averaged ECG was performed in 52 patients with arrhythmogenic right ventricular dysplasia (ARVD) proven by angiography, in 45 control subjects with normal hearts, and in 132 patients with various types of ventricular arrhythmias and no evidence of cardiac disease during routine cardiac examination...

journal_title：European heart journal

authors： Leclercq JF,Coumel P

更新日期：1993-09-01 00:00:00

abstract：:To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal ...

journal_title：European heart journal

authors： el-Said ES,Fioretti PM,Roelandt JR,McNeill AJ,Rijsterborgh H,Forster T,Di Mario C,Linker DT

更新日期：1993-08-01 00:00:00

abstract：:The clinical value of QRST isointegral maps (I-maps) for the detection of myocardial infarction (MI) in the presence of left bundle branch block (LBBB) was investigated. We recorded I-maps during sinus rhythm and right ventricular (RV) pacing, which simulated LBBB, in 62 patients with MI (42 patients had at least one ...

journal_title：European heart journal

authors： Suzuki A,Hirai M,Hayashi H,Tomita Y,Ichihara Y,Adachi M,Oguchi S,Takatsu F

更新日期：1993-08-01 00:00:00

abstract：:The management of left ventricular hypertrophy (LVH) presupposes that the patient is identified by echocardiography and is carefully evaluated for risk stratification, taking into consideration possible associated complications. The role of non-pharmacological treatment is limited, except in obese patients. Drug treat...

journal_title：European heart journal

authors： de Divitiis O,Celentano A,De Simone G,Di Somma S,Galderisi M,Liguori V,de Divitiis M,Petitto M

更新日期：1993-07-01 00:00:00

abstract：:A major consequence of chronic cardiac dysfunction is chronic overload of contractile myocardium. Various aetiologies, in reaction to this, may induce compensatory mechanisms consisting of excentric (dilatation) and concentric hypertrophy. Chronic left ventricular dysfunction is caused most frequently by myocardial in...

journal_title：European heart journal

authors： Ertl G,Gaudron P,Neubauer S,Bauer B,Horn M,Hu K,Tian R

更新日期：1993-07-01 00:00:00

abstract：:The efficacies and safety of nicorandil, 20 mg b.d., and diltiazem, 60 mg t.d., in the treatment of stable angina pectoris were compared in a double-blind randomized parallel group study involving 123 patients. The duration of the study was 3 months. Exercise tolerance tests were performed by the patients when on plac...

journal_title：European heart journal

authors： Guermonprez JL,Blin P,Peterlongo F

更新日期：1993-07-01 00:00:00

abstract：:In a prospective study, an elderly group of patients (n = 63, 47 male, 16 female, age 40-65 years) was examined before and after open-heart surgery under cardiopulmonary bypass: postoperatively, 19 patients (30%) showed no clinical neuropsychiatric symptoms, whereas in 35 patients (56%) mild or transient neurological ...

journal_title：European heart journal

authors： Zeitlhofer J,Asenbaum S,Spiss C,Wimmer A,Mayr N,Wolner E,Deecke L

更新日期：1993-07-01 00:00:00

abstract：:Late potentials detected by the signal-averaged ECG (SAECG) identify post-infarction patients at risk from sustained ventricular tachycardia (VT) and sudden death. Hypertrophic cardiomyopathy (HCM) is also associated with increased risk of sudden death. In adults, episodes of non-sustained VT on ambulatory ECG monitor...

journal_title：European heart journal

authors： Kulakowski P,Counihan PJ,Camm AJ,McKenna WJ

更新日期：1993-07-01 00:00:00

abstract：:We have evaluated overall and cardiac sympathetic activity in 47 patients undergoing coronary angiography, 27 with stable angina of at least 3 months duration, and 20 with unstable ischaemic symptoms within this period. Cardiac and overall sympathetic activity were assessed using radiotracer noradrenaline kinetic tech...

journal_title：European heart journal

authors： McCance AJ,Thompson PA,Forfar JC

更新日期：1993-06-01 00:00:00

abstract：:We conducted a survey by questionnaire to assess whether patients 'at risk' from infective endocarditis are aware of the need for good dental hygiene and antibiotic prophylaxis, and receive appropriate advice or treatment. Of 189 patients surveyed, half had told a dentist about their heart, 8% were aware of a dental p...

journal_title：European heart journal

authors： Forbat LN,Skehan JD

更新日期：1993-06-01 00:00:00

abstract：:A controversy persists as to whether cardiopulmonary bypass (CPB) decreases plasma levels of triiodothyronine (T3), thereby justifying peri-operative administration of T3 to improve haemodynamic recovery. To examine the effects of T3 therapy on post-CPB haemodynamics and to determine whether the potential inotropic ef...

journal_title：European heart journal

authors： Teiger E,Menasché P,Mansier P,Chevalier B,Lajeunie E,Bloch G,Piwnica A

更新日期：1993-05-01 00:00:00

abstract：:The prevalence of coronary heart disease (CHD) was determined in a general population sample of 9141 Icelandic men aged 34-79 years, and the prevalence of four different forms of CHD was estimated separately: symptomatic infarction fulfilling WHO-MONICA criteria for definite myocardial infarction; myocardial infarctio...

journal_title：European heart journal

authors： Sigurdsson E,Thorgeirsson G,Sigvaldason H,Sigfusson N

更新日期：1993-05-01 00:00:00

abstract：:To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardiography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy...

journal_title：European heart journal

authors： Takenaka A,Yokota M,Iwase M,Miyaguchi K,Hayashi H,Saito H

更新日期：1993-05-01 00:00:00

abstract：:We investigated cardiovascular and coronary responses to intravenous infusions of adrenaline, which raised arterial concentrations in a stepwise fashion from basal to about 5-6 nmol.l-1, in 11 non-rejecting heart transplanted patients, and in eight intact innervated subjects. Cardiac adrenaline extraction and noradren...

journal_title：European heart journal

authors： Roca J,Cruz Caturla M,Hjemdahl P,Masotti M,Ventura A,Oriol A,Crexells C

更新日期：1993-04-01 00:00:00

abstract：:In the Danish Verapamil Infarction Trial II (DAVIT II) intervention with verapamil significantly decreased the first major event rate (i.e. reinfarction or death) in patients recovering from acute myocardial infarction. As calcium channel antagonists might have a detrimental effect in patients with heart failure, the ...

journal_title：European heart journal

authors： Jespersen CM

更新日期：1993-04-01 00:00:00

abstract：:The 18 month mortality rate in 2180 patients excluded from the Danish Verapamil Infarction Trail II (DAVIT II) was 25.6%. In non-consenters (n = 368) this was 15.0% compared with 13.85 in 897 placebo-treated patients (hazard ratio 1.09 [P = 0.60] when adjusting for sex and age). The increased mortality rate in exclude...

journal_title：European heart journal

authors： Madsen JK,Hansen JF

更新日期：1993-03-01 00:00:00

abstract：:Twelve patients with the long QT syndrome were studied to determine the usefulness of 123I-metaiodobenzylguanidine (MIBG) single-photon emission tomography (SPECT) at 2 h and 6 h after injection; the results were compared to 10 healthy volunteers (controls). Uptake of MIBG in the left ventricle at 2 h after injection ...

journal_title：European heart journal

authors： Müller KD,Jakob H,Neuzner J,Grebe SF,Schlepper M,Pitschner HF

更新日期：1993-03-01 00:00:00

abstract：:An inventory has been made of the practice of angioplasty in 14 European countries from 1985 onwards. The numbers of procedures performed varied in 1985 from 3 to 186 per million inhabitants, in 1991 from 52 to 716. All countries showed a steady increase, but the highest performer. Belgium, achieved only 55% of the nu...

journal_title：European heart journal

authors： van den Brand M

更新日期：1993-03-01 00:00:00

abstract：:Impedance cardiography may be a simple way of assessing left ventricular performance during exercise. Measurements were therefore made during exercise testing in 102 consecutive male patients with suspected coronary disease prior to cardiac catheterization. These were subsequently divided into four groups: group A, no...

journal_title：European heart journal

authors： Thomas SH,Crowther A

更新日期：1993-02-01 00:00:00

abstract：:This study analyses the immediate outcome and the risk of recurrent restenosis in patients who, at the time of repeat coronary angioplasty for a first restenosis, had unstable (n = 50), 19%) or stable (n = 218, 81%) angina. Successful angioplasty was accomplished in 250 (93%) patients, 222 (89%) of whom had follow-up ...

journal_title：European heart journal

authors： Bauters C,Lablanche JM,McFadden EP,Leroy F,Bertrand ME

更新日期：1993-02-01 00:00:00

abstract：:A 54-year-old man suffering from effort angina pectoris had an anomalous origin of the left anterior descending coronary artery (LAD) from the right sinus of Valsalva (RSV). The anomalous LAD with a small ostium and without other significant narrowing initially ran into the interventricular septum and subsequently the...

journal_title：European heart journal

authors： Takenaka T,Horimoto M,Fujiwara M

更新日期：1993-01-01 00:00:00

abstract：:In 103 hearts with various forms of cardiac muscle hypertrophy the following parameters were estimated: diameter, length, volume, density and number of myocytes, and density of myocyte nuclei. The values of all histometric parameters correlated well with left ventricular (LV) weight up to 350 g. In heavier hearts thes...

journal_title：European heart journal

authors： Grajek S,Lesiak M,Pyda M,Zajac M,Paradowski S,Kaczmarek E

更新日期：1993-01-01 00:00:00

abstract：:Clinical reports show that electrical stimulation of the spinal cord reduces symptoms of angina pectoris, but so far have not provided evidence on the mechanisms involved. The hypothesis for this study was that inhibition of spinothalamic tract transmission may account for this result. Extracellular potentials of 28 s...

journal_title：European heart journal

authors： Chandler MJ,Brennan TJ,Garrison DW,Kim KS,Schwartz PJ,Foreman RD

更新日期：1993-01-01 00:00:00

abstract：:From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively, on the basis of placebo-controlled changes in 24 h natriuresis, following single oral doses administered to healthy adult subjects who are in steady-state habitual external sodium balance. The potency...

journal_title：European heart journal

authors： Reyes AJ

更新日期：1992-12-01 00:00:00

abstract：:Thiazide diuretics are efficacious, either as monotherapy or in combination with other antihypertensive drugs. They reduce blood pressure in a high percentage of hypertensive patients with minimal subjective side effects. There is increasing evidence that the use of diuretics, singly or in combination, will reduce mor...

journal_title：European heart journal

authors： Moser M

更新日期：1992-12-01 00:00:00